Molecular portraits of B cell lineage commitment
نویسندگان
چکیده
منابع مشابه
IRF8 regulates B-cell lineage specification, commitment, and differentiation.
PU.1, IKAROS, E2A, EBF, and PAX5 comprise a transcriptional network that orchestrates B-cell lineage specification, commitment, and differentiation. Here we identify interferon regulatory factor 8 (IRF8) as another component of this complex, and show that it also modulates lineage choice by hematopoietic stem cells (HSCs). IRF8 binds directly to an IRF8/Ets consensus sequence located in promote...
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Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique 'zinc knuckle', which medi...
متن کاملT cell lineage commitment: identity and renunciation.
Precursors undertaking T cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterward. This process involves three levels of regulatory change, in which the cells' intrinsic transcriptional regulatory factors, expression of signaling receptors (e.g., Notch1), and expression of distinct homi...
متن کاملT cell lineage commitment: identity and renunciation1
Precursors undertaking T-cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterwards. This process involves three levels of regulatory change, in which the cells’ intrinsic transcriptional regulatory factors, expression of signaling receptors like Notch1, and expression of distinct homing...
متن کاملRepression of Flt3 by Pax5 is crucial for B-cell lineage commitment.
Early B-lymphopoiesis requires the growth-factor receptors, IL-7R and Flt3, and the activity of a number of transcription factors. One factor, Pax5, is required for commitment to the B-cell lineage, although the molecular mechanism by which this occurs is unknown. We demonstrate here that an important function of Pax5 is to repress Flt3 transcription in B-cell progenitors, as Pax5-deficient pro...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.152327399